These effects, along with diabetes, may increase your risk for developing heart disease. Discuss the risks and benefits of treatment with your doctor. See also Notes section. Quetiapine may rarely cause a condition known as tardive dyskinesia. In some cases, this condition may be permanent. This medication may rarely cause a very serious condition called neuroleptic malignant syndrome NMS. Get medical help right away if you have any of the following symptoms: Quetiapine may increase a certain natural substance prolactin made by your body.
For males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. If you develop any of these symptoms, tell your doctor right away.
Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects.
You may report side effects to Health Canada at Before taking quetiapine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely.
Talk to your doctor if you are using marijuana. Quetiapine may cause a condition that affects the heart rhythm QT prolongation. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. As with other antipsychotics, caution is recommended when treating patients with a history of seizures see section 4. Neuroleptic malignant syndrome Neuroleptic malignant syndrome has been associated with antipsychotic treatment, including quetiapine see section 4.
Clinical manifestations include hyperthermia, altered mental status, muscular rigidity, autonomic instability, and increased creatine phosphokinase.
In such an event, quetiapine should be discontinued and appropriate medical treatment given. Most cases of severe neutropenia have occurred within a couple of months of starting therapy with quetiapine. There was no apparent dose relationship. During post-marketing experience, some cases were fatal. Possible risk factors for neutropenia include pre-existing low white blood cell count WBC and history of drug induced neutropenia.
However, some cases occurred in patients without pre-existing risk factors. Patients should be observed for signs and symptoms of infection and neutrophil counts followed until they exceed 1. Neutropenia should be considered in patients presenting with infection or fever, particularly in the absence of obvious predisposing factor s , and should be managed as clinically appropriate.
Such patients should have a WBC count and an absolute neutrophil count ANC performed promptly, especially in the absence of predisposing factors. Anti-cholinergic muscarinic effects Norquetiapine, an active metabolite of quetiapine, has moderate to strong affinity for several muscarinic receptor subtypes.
This contributes to ADRs reflecting anti-cholinergic effects when quetiapine is used at recommended doses, when used concomitantly with other medications having anti-cholinergic effects, and in the setting of overdose.
Quetiapine should be used with caution in patients receiving medications having anti-cholinergic muscarinic effects. Quetiapine should be used with caution in patients with a current diagnosis or prior history of urinary retention, clinically significant prostatic hypertrophy, intestinal obstruction or related conditions, increased intraocular pressure or narrow angle glaucoma see sections 4.
Interactions See section 4. Concomitant use of quetiapine with a strong hepatic enzyme inducer such as carbamazepine or phenytoin substantially decreases quetiapine plasma concentrations, which could affect the efficacy of quetiapine therapy.
In patients receiving a hepatic enzyme inducer, initiation of quetiapine treatment should only occur if the physician considers that the benefits of quetiapine outweigh the risks of removing the hepatic enzyme inducer. It is important that any change in the inducer is gradual, and if required, replaced with a non-inducer e. Weight Weight gain has been reported in patients who have been treated with quetiapine, and should be monitored and managed as clinically appropriate as in accordance with utilised antipsychotic guidelines see sections 4.
In some cases, a prior increase in body weight has been reported which may be a predisposing factor. Appropriate clinical monitoring is advisable in accordance with utilised antipsychotic guidelines. Patients treated with any antipsychotic agent including quetiapine, should be observed for signs and symptoms of hyperglycaemia such as polydipsia, polyuria, polyphagia and weakness and patients with diabetes mellitus or with risk factors for diabetes mellitus should be monitored regularly for worsening of glucose control.
Weight should be monitored regularly. Lipids Increases in triglycerides, LDL and total cholesterol, and decreases in HDL cholesterol have been observed in clinical trials with quetiapine see section 4. Lipid changes should be managed as clinically appropriate. QT prolongation In clinical trials and use in accordance with the SPC, quetiapine was not associated with a persistent increase in absolute QT intervals.
In post-marketing, QT prolongation was reported with quetiapine at the therapeutic doses see section 4. As with other antipsychotics, caution should be exercised when quetiapine is prescribed in patients with cardiovascular disease or family history of QT prolongation.
Also, caution should be exercised when quetiapine is prescribed either with medicines known to increase QT interval or with concomitant neuroleptics, especially in the elderly, in patients with congenital long QT syndrome, congestive heart failure, heart hypertrophy, hypokalaemia or hypomagnesaemia see section 4. Cardiomyopathy and myocarditis Cardiomyopathy and myocarditis have been reported in clinical trials and during the post-marketing experience, however, a causal relationship to quetiapine has not been established.
Treatment with quetiapine should be reassessed in patients with suspected cardiomyopathy or myocarditis. Withdrawal Acute withdrawal symptoms such as insomnia, nausea, headache, diarrhoea, vomiting, dizziness and irritability have been described after abrupt cessation of quetiapine. Gradual withdrawal over a period of at least one to two weeks is advisable see section 4.
Elderly patients with dementia-related psychosis Quetiapine is not approved for the treatment of dementia-related psychosis. I'm assuming these are all regular side effects, but how long will they last? I'm scared to drive, feeling like this My doctor initially wanted to start me on Lithium, but I am hypothyroid already, and I guess Lithium could worsen that?
I have had some of the same side effects, but nothing lasted very long and I am perfectly fine now. I would advise giving it some time, but if they don't go away, contact your pdoc We have a good support system here. It's great to have you. I called my regular psychiatrist today. It was a different psychiatrist who prescribed my meds over the weekend.
Will regular exercise help stint the weight gain? Also, since both the seroquel XR and Remeron are appetite stimulants, does that mean they will stack and hit me harder with the weight gain side effects, or will they simply remain the same?
The weight gain may increase with both medications and usually just exercise is not enough, but you would have to really be disciplined on your diet. Some weight gain is going to happen no matter what on these medications because you will metabolize fat differently and some water weight is going to be expected on these medications too Customer: Is there any other anti depressant or drug that would compliment the seroquel xr or any drug for that matter?
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